Table 3.
Effect of Restoration of TLR9 in Bone Marrow on Metabolic Parameters
| Donor | Tlr9 −/− Apoe −/− | Apoe −/− | P Value |
|---|---|---|---|
| ↓ | ↓ | ↓ | |
| Recipient | Tlr9 −/− Apoe −/− | Tlr9 −/− Apoe −/− | |
| Body weight, g | 26.6±0.8 | 25.6±1.0 | 0.45 |
| Heart rate, bpm | 656±31 | 680±31 | 0.59 |
| Systolic blood pressure, mm Hg | 138.9±4.3 | 136.9±4.3 | 0.75 |
| Diastolic blood pressure, mm Hg | 93.6±4.4 | 87.6±4.9 | 0.38 |
| Total cholesterol, mg/dL | 1407.6±295.8 | 1884.5±81.1 | 0.11 |
| Triglyceride, mg/dL | 145.1±34.8 | 168.6±20.3 | 0.57 |
| HDL cholesterol, mg/dL | 20.4±3.8 | 19.0±1.4 | 0.74 |
All values are mean±SEM. HDL indicates high‐density lipoprotein; TLR9, Toll‐like receptor 9.