Table 2.
Central Hemodynamic Characteristics by Tertiles of the dp‐ucMGP Distribution
| Characteristics | Category of dp‐ucMGP | P Value | ||
|---|---|---|---|---|
| Limits, μg/L | <3.35 | 3.35–5.31 | ≥5.31 | … |
| Systolic pressure, mm Hg | 119.8±14.8 | 123.1±16.7* | 131.7±19.0† | <0.001 |
| Diastolic pressure, mm Hg | 78.0±9.6 | 79.0±8.9 | 81.9±9.4† | <0.001 |
| Mean arterial pressure, mm Hg | 94.7±10.5 | 96.6±10.4* | 101.8±10.9† | <0.001 |
| Central pulse pressure, mm Hg | 41.8±11.7 | 44.1±14.4 | 49.8±18.0† | <0.001 |
| Augmentation pressure, mm Hg | 8.3±7.7 | 10.5±8.6† | 14.1±9.3† | <0.001 |
| Augmentation ratio, % | 107.2±6.5 | 109.1±7.1† | 111.9±6.8† | <0.001 |
| Augmentation index, % | 21.0±11.7 | 23.6±11.9† | 26.9±10.5† | <0.001 |
| Pulse wave velocity, m/s | 6.84±1.26 | 7.22±1.64* | 8.09±1.78† | <0.001 |
| Forward pulse peak time, ms | 107.3±13.6 | 107.1±12.6 | 107.6±12.8 | 0.90 |
| Backward pulse peak time, ms | 231.1±23.9 | 231.6±22.3 | 233.8±20.5 | 0.31 |
| Forward wave amplitude, mm Hg | 32.2±9.4 | 32.7±10.3 | 34.7±10.8* | 0.009 |
| Backward wave amplitude, mm Hg | 19.4±6.3 | 20.9±7.8* | 24.7±9.9† | <0.001 |
| Reflection magnitude, % | 63.0±18.0 | 65.7±18.3 | 70.2±17.6† | <0.001 |
Values are given as mean±SD. To convert dp‐ucMGP from μg/L into pmol/L, multiply by 94.299. Pulse wave velocity was available in 657 participants. The augmentation ratio and index, pulse wave velocity, forward and backward pulse peak times, and forward and backward wave amplitudes were standardized to a heart rate of 65 beats per minute (population mean). P values denote the significance of the difference in means (ANOVA) across tertiles of the dp‐ucMGP distribution. dp‐ucMGP indicates desphospho‐uncarboxylated matrix Gla protein.
Significance of the difference with the adjacent lower tertile: *P≤0.05, † P≤0.01.