Table 2.

Adverse events leading to discontinuation in > 2 patients in any single exposure period through 260 weeks of apremilast treatment by treatment period

Patients, n (%)	Apremilast-exposure period*
	Weeks 0 to ≤ 52		Weeks > 52 to ≤ 104		Weeks > 104 to ≤ 156		Weeks > 156 to ≤ 208		Weeks > 208 to ≤ 260
	30 mg twice daily (n = 721)	20 mg twice daily (n = 720)	30 mg twice daily (n = 520)	20 mg twice daily (n = 508)	30 mg twice daily (n = 443)	20 mg twice daily (n = 422)	30 mg twice daily (n = 401)	20 mg twice daily (n = 366)	30 mg twice daily (n = 364)	20 mg twice daily (n = 320)
Nausea	16 (2.2)	8 (1.1)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Diarrhea	15 (2.1)	6 (0.8)	1 (0.2)	0 (0.0)	0 (0.0)	1 (0.2)	0 (0.0)	0 (0.0)	1 (0.3)	0 (0.0)
Headache	11 (1.5)	4 (0.6)	0 (0.0)	0 (0.0)	1 (0.2)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Vomiting	6 (0.8)	1 (0.1)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Dizziness	4 (0.6)	2 (0.3)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Upper abdominal pain	3 (0.4)	4 (0.6)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	1 (0.3)	0 (0.0)	0 (0.0)
Migraine	3 (0.4)	1 (0.1)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Fatigue	3 (0.4)	2 (0.3)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	1 (0.3)	0 (0.0)	0 (0.0)

*Includes all patients who received apremilast during the time interval relative to the start of apremilast treatment