Fig. 4.

SNORA7B overexpression promotes tumorigenicity and inhibits apoptosis in BC cells. a Efficiency of SNORA7B overexpression in MDA-MB-231 and BT-549 cell lines by qRT-PCR after transfection with pCMV-SNORA7B and pCMV-NC. b, c SNORA7B overexpression in MDA-MB-231 and BT-549 cell lines results in increased colonies. d, e SNORA7B overexpression increased proliferative capacity of MDA-MB-231 and BT-549 cell lines. f, g SNORA7B overexpression in both cell lines resulted in increased migration capacity. h, i Invasion capacity enhanced in both cell lines transfected with SNORA7B overexpression plasmid. j, k SNORA7B overexpression reduced the percentage of apoptotic cells in both BC cell lines. (These experiments were repeated independently three times. *p < 0.05;**p < 0.01;***p < 0.001;****p < 0.0001 (Student’s t test)