Table 2.

Results of assessment of bias for animal studies, based on SYRCLE risk-of-bias tool [19]

Reference	Sequence generation	Group similarities at baseline	Allocation concealment	Random housing of animals	Blinding of caregivers and/or investigators and outcome assessor	Random animal selection for outcome assessment	Incomplete outcome data addressed	Free of selective reporting	Free of other bias
Erlandsson, 2014 [29]	Unclear	Low	Unclear	Unclear	Unclear	Low	Unclear	Low	Low
Fu, 2015 [12]	Low	Low	Unclear	Low	Unclear	Low	Low	Low	Low
Liu, 2014 [35]	Unclear	Low	Unclear	Low	Unclear	Low	Unclear	Low	Low
Naav, 2015 [30]	Unclear	Unclear	Unclear	Unclear	Unclear	Low	High	Unclear	Low
Shinyama, 1996 [28]	Unclear	Low	Unclear	Unclear	Unclear	Unclear	Low	Low	Low
Wang, 2016 [33]	Unclear	Low	Unclear	Unclear	Unclear	Unclear	Low	Unclear	Low
Wester-Rosenlof, 2014 [11]	Low	Low	Low	Unclear	Low	Low	Low	Low	Low