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. 2019 May 3;13:188. doi: 10.3389/fncel.2019.00188

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Copyright © 2019 Sanguinetti, Guzzardi, Panetta, Tripodi, De Sena, Quaglierini, Burchielli, Salvadori and Iozzo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Body weight, areas under the curves and BMI achieved by the study groups at final time-points of 8 (A–C) and 14 months of age (D–F), showing that body weight was affected by diet (positively) and by 3×Tg background (negatively), whereas BMI was only dependent on diet, since 3×Tg mice were lighter, but also shorter (data not shown) than controls. Data are presented as mean ± SEM. Sample sizes are given in Table 1. *p < 0.05 or less (**,***) ND-ND and HFD-HFD (between strains), $^{\land}$ p < 0.05 or less ( $^{\land}$ $^{\land}$ , $^{\land}$ $^{\land}$ $^{\land}$ ) HFD vs. ND (within-strain), ^$#$p < 0.05 or less (^{$# #$},^{$# # #$}) vs. ND control group (reference group), °p < 0.05 or less (°°) for treated 3×Tg-HFD + INI vs. untreated 3×Tg-HFD.