TABLE 1.

Sample size referring to results shown in figures and tables.

	C-ND	C-HFD	3×Tg-ND	3×Tg-HFD	3×Tg-HFD + INI
8 months
Body weight (20–24w)(g)	37	39	22	22	25
Random glycemia (21-22w) (mmol/l)	35	39	21	20	24
Caloric Intake (20-24w) (Kcal)	37	39	22	22	25
Circulating cytokines	9–11	10–12	8	6–7	10–11
Cognitive variables	39	39	21	20	23
Brain mass	5	5	4	4	7
Brain histology	3	5	3	3	5
Brain PET baseline	7	9	8	7	11
Brain PET + acute insulin	7	9	8	7	10
14 months
Body weight (44w) (g)	14	16	11	11	8
Random glycemia (42–44w) (mmol/l)	14	16	11	11	8
Caloric Intake (Kcal)	14	16	11	11	8
Circulating cytokines	11–13	14–16	8–9	5–6	7
Cognitive variables	16	14	9	7	7
Brain mass	6	6	9	6	7
Brain histology	6	6	4	4	4
Brain PET baseline	10	12	8	6	7
Brain PET + acute insulin	10	11	8	5	7