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. 2019 May 3;13:429. doi: 10.3389/fnins.2019.00429

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Copyright © 2019 Zou, Shi, He, Jiang, Huo, Wang, Wu and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A1 astrocytes were gradually down-regulated by activation of the FGF2/FGFR1 pathway and were up-regulated by inhibition of the FGF2/FGFR1 pathway. (A,D) Quantitative analysis of percentage of C3⁺/GFAP⁺ area in the CA1 region of rat hippocampus in different groups, by immunofluorescence staining. (B,E) C3 expression in rat hippocampus in different groups by western blotting. (C,F) Semi-quantitative analysis of C3 expression in rat hippocampus in different groups. N = 6–8 for each experiment. One-way ANOVA. Values expressed as mean ± SD. *P < 0.05.