Table 2.

Biological meaning of the attractors obtained in the FA-CHKREC network.

Attractor	Biological meaning	Activation state of the nodes in the attractor	Variants
Cell cycle progression (CCP)	CCP occurs when the Cyclin B-CDK1 complex is activated. In normal conditions this only occurs after completion of DNA damage repair. However, under circumstances of excessive DNA damage or DNA repair null mutants, CCP can occur with unrepaired DNA damage.	Nodes ON: CDK1-AurA, PLK1, CDC25 an CyclinB-CDK1. Nodes OFF: the remaining.	Any DNA damage node (ICL, RDSB) can be activated along with the Cyclin B-CDK1 node in the same attractor. This condition in biological terms reflects CCP with DNA damage adaptation (DDA).
Cell Cycle Arrest (CCA)	CCA occurs in the G2-M transition when DNA damage has not been repaired. CCA is dependent on the proteins of the checkpoint and can be triggered by different types of unrepaired DNA damage. During an ongoing CCA, activation of DNA repair nodes and CHKREC nodes can occur, however the system will remain in CCA as long as the Cyclin B-CDK1 node is not activated.	Nodes ON: PIKK-CHK, P53, P21, and any DNA damage node (ICL, RDSB, DSB). Nodes OFF: Cyclin B-CDK1.	In addition to the nodes previously listed, other nodes can be activated however, the Cyclin B-CDK1 node is never activated in this type of attractor.