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. 2019 May 2;14:3203–3220. doi: 10.2147/IJN.S207589

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© 2019 Ye et al.

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Man-PEG-Lipo promotes the polarization of TAMs. Murine G422 glioma tumor-bearing mice were treated with liposomes, and the tumors were analyzed by western blot for CD206 expression (A), and quantitative real-time PCR for Arg1 (B), Mgl2 (C), and Ym1 (D) mRNA expression. Each value represents the mean ± SD (n=3). *p<0.05, **p<0.01, and ***p<0.001 compared with the vehicle group.

Abbreviations: Lipo, liposomes; PEG-Lipo, PEGylated liposomes; Man-PEG-Lipo, mannosylated liposomes; TAMs, tumor-associated macrophages; CD206, cluster of differentiation 206; Arg1, Arginase 1; Mgl2, Macrophage galactose-type C-type lectin 2; Ym1, Chitinase 3-like 3.