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. 2019 May 3;9:356. doi: 10.3389/fonc.2019.00356

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Copyright © 2019 Yang, Li, Zou and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exosomes in crosstalk between CAFs and cancer cells. Specific exosomes released from CAFs can be internalized by cancer cells and regulate carcinogenesis by transferring ncRNA, proteins, and metabolites. Correspondingly, the exosomes released by cancer cells can also promote the transformation of CAFs from NFs and MSCs.