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MDCKII/MDR1 cell monolayers form functional barriers. (A) Lucifer yellow permeability was measured at 0 nm/s. Low lucifer yellow permeability (<20 nm/s) indicates a tight monolayer (9). (B) Rh123 apparent permeability (Papp) indicated stronger efflux in the basolateral-to-apical (B/A) compared to the apical-to-basolateral direction (A/B). Efflux ratio was > 2 nm/s, indicative of functional P-gp pumps (10). Mean ± SD. N = 72 for three independent tests.
