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. 2019 May 3;9:351. doi: 10.3389/fonc.2019.00351

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Copyright © 2019 Sherman and Rossi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model demonstrates in vivo-like cytotoxic response. LN-229 viability 48 h after a 2h exposure to 250 μM cisplatin or piperlongumine. Percent viability was calculated by comparing luminescent signal in the presence of drug to that of buffer plus vehicle controls. Two-tailed t-test indicated a statistically significant (p < 0.0001) difference between cisplatin-induced cytotoxicity with and without a BBB. Mean ± SD. N = 30 from three independent studies. ^*** denotes level of statistical significance (p < 0.0001).