Table 1.

Distributions of Hormones and Phthalate Metabolites in the Overall Study Population and at Visits 1 and 3

		N	% >LOD	Min.	25th	50th	75th	90th	95th	Max.	GM	GSD	P Valuea
CRHb	Total	673	100	7.20	56.0	83.6	114	158	176	254	79.4	1.71	0.617
	Visit 1	401	100	16.6	55.5	82.4	114	155	174	254	78.9	1.69
	Visit 3	272	100	7.20	56.8	86.6	114	159	179	249	80.3	1.73
E3c	Total	673	100	3.49	15.5	27.1	43.6	60.2	72.6	265	26.4	1.98	0.000
	Visit 1	401	100	3.49	13.0	17.5	26.9	37.7	46.6	92.0	18.4	1.75
	Visit 3	272	100	11.1	33.7	44.6	57.7	73.1	97.2	265	44.7	1.60
SHBGd	Total	673	100	47.6	504	623	763	908	989	1502	612	1.40	0.000
	Visit 1	401	100	47.6	484	589	713	854	937	1502	579	1.41
	Visit 3	272	100	279	523	673	831	976	1087	1381	665	1.36
Progesteronec	Total	673	100	17.4	44.3	61.6	88.4	134	158	1037	64.9	1.73	0.000
	Visit 1	401	100	17.4	37.3	48.7	62.4	80.3	95.6	283	49.6	1.49
	Visit 3	272	100	28.1	71.7	90.4	128	164	235	1037	96.4	1.65
TSHe	Total	665	100	0.02	1.00	1.40	2.02	2.77	3.43	10.2	1.34	2.03	0.640
	Visit 1	395	100	0.02	0.91	1.38	2.02	2.78	3.28	10.2	1.27	2.20
	Visit 3	270	100	0.14	1.10	1.48	2.00	2.73	3.56	5.47	1.46	1.75
fT4f	Total	673	100	0.71	1.00	1.08	1.18	1.26	1.32	1.72	1.08	1.13	0.002
	Visit 1	401	100	0.71	1.02	1.10	1.19	1.27	1.35	1.72	1.10	1.14
	Visit 3	272	100	0.73	0.97	1.06	1.15	1.23	1.29	1.42	1.06	1.13
T3c	Total	671	100	1.04	1.71	1.98	2.22	2.46	2.59	3.16	1.94	1.21	0.292
	Visit 1	400	100	1.04	1.70	1.97	2.22	2.44	2.56	3.16	1.93	1.21
	Visit 3	271	100	1.04	1.71	1.99	2.22	2.47	2.60	3.15	1.95	1.21
T4g	Total	672	100	6.80	10.5	11.8	13.3	14.6	15.5	19.0	11.7	1.19	0.261
	Visit 1	400	100	6.80	10.6	11.9	13.3	14.7	15.5	19.0	11.8	1.19
	Visit 3	272	100	7.20	10.4	11.7	13.2	14.4	15.3	18.6	11.6	1.19
Tf	Total	669	99	2.80	39.6	55.5	78.8	105	126	418	55.1	1.72	0.001
	Visit 1	398	99	2.80	37.8	52.1	75.1	98.1	123	185	51.9	1.70
	Visit 3	271	99	9.20	45.1	61.4	87.0	111	129	418	60.2	1.71
mBP	Total	674	99	0.44	9.35	17.5	32.3	60.3	81.0	297	16.9	2.72	0.931
	Visit 1	404	99	0.44	9.54	17.7	30.6	61.1	81.4	297	17.1	2.73
	Visit 3	270	99	0.75	9.14	17.4	33.2	58.5	76.0	244	16.6	2.71
mBzP	Total	669	95	0.21	1.52	3.20	6.88	13.9	23.7	471	3.36	3.21	0.279
	Visit 1	401	96	0.28	1.64	3.60	7.52	15.9	24.8	471	3.66	3.26
	Visit 3	268	93	0.21	1.43	2.70	6.05	11.2	20.5	114	2.97	3.11
mCNP	Total	665	99	0.26	1.26	1.91	3.07	6.05	8.79	172	2.14	2.25	0.760
	Visit 1	396	99	0.50	1.33	2.00	3.19	6.22	10.3	71.0	2.21	2.25
	Visit 3	269	99	0.26	1.20	1.80	2.90	5.49	8.14	172	2.02	2.24
mCOP	Total	666	100	0.96	5.87	10.5	21.2	53.7	101	902	12.6	2.97	0.496
	Visit 1	398	100	1.50	6.61	11.9	24.3	59.5	138	902	13.9	3.03
	Visit 3	268	100	0.96	5.09	10.0	17.3	47.1	73.4	609	10.8	2.83
mCPP	Total	668	88	0.14	0.87	1.60	2.94	6.44	10.2	168	1.75	2.76	0.513
	Visit 1	398	90	0.14	0.93	1.69	3.16	6.91	10.8	83.6	1.84	2.72
	Visit 3	270	84	0.23	0.83	1.50	2.72	5.25	7.70	168	1.63	2.82
mECPP	Total	671	100	1.87	9.64	15.4	25.0	36.7	49.4	678	15.4	2.10	0.343
	Visit 1	401	100	2.20	9.89	15.6	25.1	36.4	45.1	678	15.8	2.12
	Visit 3	270	100	1.87	9.61	14.9	23.8	36.9	51.1	154	14.9	2.07
mEHHP	Total	670	99	0.67	5.14	8.87	14.6	22.9	30.1	800	8.50	2.38	0.304
	Visit 1	401	99	0.75	5.44	9.24	15.5	22.9	31.6	800	8.96	2.38
	Visit 3	269	99	0.67	4.53	8.43	14.0	22.0	29.8	82.9	7.85	2.37
mEHP	Total	669	85	0.28	1.50	2.80	4.61	7.51	10.1	433	2.72	2.34	0.701
	Visit 1	400	88	0.43	1.57	2.86	4.60	7.61	10.8	433	2.83	2.34
	Visit 3	269	82	0.28	1.43	2.67	4.70	7.08	9.41	34.5	2.57	2.32
mEOHP	Total	668	99	0.50	4.42	7.57	12.4	18.8	23.4	531	7.27	2.29	0.739
	Visit 1	399	99	0.50	4.45	7.50	12.5	19.1	21.8	531	7.36	2.32
	Visit 3	269	100	0.67	4.40	7.65	12.4	18.4	25.2	65.2	7.14	2.25
mEP	Total	666	99	2.00	15.9	39.3	163	527	920	43,000	53.8	4.94	0.895
	Visit 1	398	99	2.00	18.3	39.6	150	526	846	43,000	54.4	4.75
	Visit 3	268	99	2.43	13.6	36.0	206	526	962	7765	52.9	5.25
miBP	Total	670	99	0.75	6.11	11.2	20.6	37.9	51.0	204	11.4	2.50	0.789
	Visit 1	400	99	0.75	6.28	10.8	21.0	39.4	51.1	202	11.3	2.51
	Visit 3	270	99	1.33	6.00	12.1	20.0	37.7	49.3	204	11.6	2.48
MCOCH	Total	445	18	0.20	0.34	0.42	0.59	0.88	1.41	7.26	0.47	1.71	0.091
	Visit 1	273	19	0.20	0.32	0.39	0.54	0.88	1.26	7.26	0.45	1.71
	Visit 3	172	17	0.21	0.35	0.47	0.60	1.01	1.43	3.54	0.51	1.71
MHBP	Total	443	81	0.21	0.80	1.54	2.82	5.58	8.67	26.2	1.52	2.64	0.385
	Visit 1	271	84	0.24	0.81	1.62	2.98	5.50	9.13	26.2	1.58	2.69
	Visit 3	172	77	0.21	0.72	1.46	2.47	5.58	8.12	22.8	1.44	2.56
MHiBP	Total	445	97	0.35	2.82	5.00	9.75	16.5	23.2	51.1	5.10	2.47	0.865
	Visit 1	273	98	0.35	2.83	5.16	10.3	17.0	23.7	51.1	5.34	2.46
	Visit 3	172	96	0.44	2.75	4.84	9.20	13.1	22.8	48.7	4.75	2.48
MHiNCH	Total	612	33	0.16	0.28	0.38	0.67	1.14	1.78	21.0	0.47	2.04	0.056
	Visit 1	367	35	0.16	0.27	0.38	0.67	1.13	1.67	21.0	0.46	2.05
	Visit 3	245	31	0.19	0.28	0.40	0.67	1.20	1.98	8.00	0.48	2.03
mNP	Total	444	29	0.35	0.64	0.85	1.46	3.18	6.36	42.9	1.08	2.21	0.846
	Visit 1	271	34	0.41	0.64	0.85	1.59	3.60	7.16	42.9	1.10	2.26
	Visit 3	173	22	0.35	0.64	0.85	1.41	2.80	5.05	33.0	1.06	2.13
MECPTP	Total	153	100	1.13	7.77	15.3	33.3	162	443	2543	20.5	3.99	0.691
	Visit 1	92	100	1.22	7.94	14.9	36.4	140	495	2543	20.9	4.09
	Visit 3	61	100	1.13	7.77	16.2	28.8	167	342	732	20.0	3.89
MEHHTP	Total	153	97	0.25	1.68	2.86	6.00	23.0	51.9	1207	3.72	3.64	0.328
	Visit 1	92	99	0.25	1.73	2.81	5.93	22.3	65.0	1207	3.82	3.79
	Visit 3	61	95	0.35	1.46	2.91	7.85	23.6	37.7	97.7	3.58	3.46
MONP	Total	153	93	0.28	1.13	2.21	3.84	6.63	11.7	127	2.19	2.83	0.399
	Visit 1	92	95	0.28	1.12	2.19	4.68	8.07	11.8	34.5	2.29	2.79
	Visit 3	61	90	0.31	1.20	2.21	2.83	4.43	8.45	127	2.04	2.92

All phthalate concentrations have been adjusted for specific gravity and are presented in ng/mL. Boldface type indicates a significant P value < 0.05.

Abbreviations: GM, geometric mean; GSD, geometric SD; T, testosterone.

^a P value was calculated using a paired t test between biomarker concentrations at visit1 and visit 3. Skewed biomarkers were log transformed to achieve normality.

^bUnits pg/mL.

^cUnits ng/mL.

^dUnits nmol/L.

^eUnits uIU/mL.

^fUnits ng/dL.

^gUnits μg/dL.