Table 3.
Results From Linear Mixed Models Showing the Percent Change in Serum Hormone Levels Corresponding to an IQR Increase in Urinary Phthalate Metabolite Concentrations Specific to Each Study Visit
| CRHa | E3a | SHBG | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | %Δ (95% CI) | P | N | %Δ (95% CI) | P | N | %Δ (95% CI) | P | ||
| MBP | Visit 1 | 652 | −9.14 (−23.5, 7.89) | 0.276 | 652 | −1.67 (−16.9, 16.3) | 0.845 | 652 | −0.711 (−10.1, 8.7) | 0.882 |
| Visit 3 | 652 | −7.76 (−24.1, 12) | 0.417 | 652 | −2.82 (−19.8, 17.7) | 0.770 | 652 | −5.57 (−15.7, 4.61) | 0.285 | |
| MBzP | Visit 1 | 648 | −5.97 (−13, 1.67) | 0.125 | 648 | −2.29 (−9.47, 5.46) | 0.553 | 648 | −2.05 (−6.44, 2.33) | 0.360 |
| Visit 3 | 648 | −4.63 (−13.1, 4.63) | 0.318 | 648 | −8.54 (−16.5, 0.208) | 0.057 | 648 | −1.07 (−5.94, 3.8) | 0.667 | |
| MCNP | Visit 1 | 643 | −3.95 (−7.93, 0.198) | 0.064 | 643 | 1.39 (−2.78, 5.73) | 0.521 | 643 | −1.06 (−3.34, 1.23) | 0.366 |
| Visit 3 | 643 | −4.23 (−8.65, 0.398) | 0.075 | 643 | 1.39 (−3.29, 6.29) | 0.569 | 643 | −0.876 (−3.29, 1.54) | 0.478 | |
| MCOP | Visit 1 | 644 | −3.84 (−15.1, 8.95) | 0.540 | 644 | −4.8 (−15.8, 7.58) | 0.431 | 644 | −6.22 (−13, 0.587) | 0.075 |
| Visit 3 | 644 | −9.66 (−22.4, 5.11) | 0.191 | 644 | 5.98 (−8.75, 23.1) | 0.448 | 644 | −4.9 (−12.6, 2.83) | 0.216 | |
| MCPP | Visit 1 | 646 | −5.46 (−9.22, −1.55) | 0.007 | 646 | 0.583 (−3.35, 4.68) | 0.776 | 646 | −0.93 (−3.12, 1.26) | 0.405 |
| Visit 3 | 646 | −4.98 (−9.22, −0.544) | 0.030 | 646 | 0.843 (−3.61, 5.5) | 0.716 | 646 | −1.6 (−3.93, 0.724) | 0.179 | |
| MECPP | Visit 1 | 649 | −14.2 (−29, 3.55) | 0.112 | 649 | 3.33 (−14.1, 24.3) | 0.729 | 649 | −0.15 (−10.6, 10.3) | 0.978 |
| Visit 3 | 649 | −24 (−38.7, −5.87) | 0.013 | 649 | −5.29 (−23.4, 17) | 0.615 | 649 | −5.47 (−16.9, 5.94) | 0.349 | |
| MEHHP | Visit 1 | 648 | −9.92 (−21.5, 3.3) | 0.137 | 648 | −3.72 (−15.8, 10.1) | 0.582 | 648 | −3.55 (−11, 3.94) | 0.355 |
| Visit 3 | 648 | −18 (−29.8, −4.17) | 0.014 | 648 | −6.42 (−19.7, 9.11) | 0.398 | 648 | −5.44 (−13.6, 2.74) | 0.194 | |
| MEHP | Visit 1 | 647 | −3.63 (−10.1, 3.33) | 0.300 | 647 | 0.475 (−6.22, 7.65) | 0.893 | 647 | 0.76 (−3.1, 4.62) | 0.700 |
| Visit 3 | 647 | −7.44 (−14.8, 0.536) | 0.069 | 647 | −4.63 (−12.2, 3.53) | 0.260 | 647 | −1.32 (−5.67, 3.02) | 0.551 | |
| MEOHP | Visit 1 | 646 | −10.6 (−21.9, 2.31) | 0.106 | 646 | 0.269 (−12.2, 14.5) | 0.968 | 646 | −2.02 (−9.4, 5.35) | 0.591 |
| Visit 3 | 646 | −15.8 (−28, −1.63) | 0.032 | 646 | −4.67 (−18.3, 11.2) | 0.544 | 646 | −4.53 (−12.7, 3.64) | 0.279 | |
| MEP | Visit 1 | 644 | −4.07 (−18.5, 12.9) | 0.618 | 644 | 1.63 (−13.4, 19.2) | 0.843 | 644 | −2.05 (−10.9, 6.84) | 0.652 |
| Visit 3 | 644 | 2.2 (−14.6, 22.3) | 0.813 | 644 | 12 (−6.15, 33.6) | 0.211 | 644 | −0.926 (−10.5, 8.6) | 0.849 | |
| MiBP | Visit 1 | 648 | 1.57 (−13.1, 18.8) | 0.845 | 648 | −8.18 (−21.1, 6.9) | 0.273 | 648 | −3.19 (−11.8, 5.39) | 0.468 |
| Visit 3 | 648 | −0.0167 (−16.2, 19.3) | 0.999 | 648 | −5.49 (−20.5, 12.3) | 0.522 | 648 | −2.37 (−11.9, 7.11) | 0.625 | |
| MHBP | Visit 1 | 435 | −0.502 (−5.7, 4.98) | 0.854 | 435 | 1.01 (−4.01, 6.29) | 0.700 | 435 | −1.71 (−4.62, 1.2) | 0.253 |
| Visit 3 | 435 | 1.1 (−5.33, 7.96) | 0.746 | 435 | 0.805 (−5.24, 7.23) | 0.800 | 435 | −0.113 (−3.17, 2.94) | 0.943 | |
| MHiBP | Visit 1 | 437 | −2.59 (−14.3, 10.8) | 0.690 | 437 | 2.11 (−9.66, 15.4) | 0.740 | 437 | −3.62 (−10.7, 3.47) | 0.319 |
| Visit 3 | 437 | 0.23 (−13.4, 16) | 0.975 | 437 | −4.13 (−16.5, 10.1) | 0.551 | 437 | −2.04 (−9.54, 5.46) | 0.595 | |
| MECPTP | Visit 1 | 153 | 14.2 (−4.82, 37.1) | 0.163 | 153 | 14.1 (−7.42, 40.7) | 0.225 | 153 | 3.65 (−5.96, 13.3) | 0.462 |
| Visit 3 | 153 | 0.471 (−20.3, 26.7) | 0.969 | 153 | −16.5 (−35.9, 8.88) | 0.193 | 153 | −9.19 (−19, 0.598) | 0.075 | |
| MEHHTP | Visit 1 | 153 | 6.82 (−3.99, 18.8) | 0.235 | 153 | 5.49 (−6.68, 19.3) | 0.399 | 153 | 1.49 (−4.59, 7.56) | 0.635 |
| Visit 3 | 153 | 5.81 (−7.72, 21.3) | 0.425 | 153 | −10.1 (−23.2, 5.16) | 0.193 | 153 | −4.39 (−10.6, 1.83) | 0.177 | |
| MONP | Visit 1 | 153 | 3.46 (−4.59, 12.2) | 0.417 | 153 | −1.56 (−10.3, 8.08) | 0.744 | 153 | 0.23 (−4.32, 4.78) | 0.922 |
| Visit 3 | 153 | 0.52 (−8.24, 10.1) | 0.912 | 153 | 1.07 (−8.97, 12.2) | 0.844 | 153 | 0.25 (−4.18, 4.68) | 0.913 | |
| Progesterone a | TSH a | fT4 | ||||||||
| N | %Δ (95% CI) | P | N | %Δ (95% CI) | P | N | %Δ (95% CI) | P | ||
| MBP | Visit 1 | 652 | −3.36 (−16, 11.2) | 0.634 | 644 | −0.142 (−18.4, 22.2) | 0.989 | 652 | 3.81 (−0.0488, 7.68) | 0.055 |
| Visit 3 | 652 | 12.1 (−4.46, 31.6) | 0.163 | 644 | 8.75 (−12, 34.4) | 0.438 | 652 | 2.82 (−1.44, 7.09) | 0.196 | |
| MBzP | Visit 1 | 648 | −2.41 (−8.49, 4.07) | 0.458 | 639 | −0.617 (−9.56, 9.21) | 0.898 | 647 | 1.71 (−0.0698, 3.49) | 0.062 |
| Visit 3 | 648 | −2.06 (−9.29, 5.74) | 0.596 | 639 | 1.4 (−8.42, 12.3) | 0.790 | 647 | 0.666 (−1.37, 2.7) | 0.522 | |
| MCNP | Visit 1 | 643 | −3.11 (−6.44, 0.332) | 0.078 | 635 | 0.51 (−4.17, 5.42) | 0.835 | 643 | 0.697 (−0.25, 1.64) | 0.151 |
| Visit 3 | 643 | −1.69 (−5.48, 2.25) | 0.396 | 635 | −0.697 (−5.46, 4.3) | 0.780 | 643 | 0.275 (−0.748, 1.3) | 0.599 | |
| MCOP | Visit 1 | 644 | −10.8 (−19.4, −1.19) | 0.030 | 636 | 3.27 (−10.6, 19.2) | 0.662 | 644 | 4.51 (1.73, 7.29) | 0.002 |
| Visit 3 | 644 | −8.43 (−19.1, 3.71) | 0.168 | 636 | 0.905 (−13.9, 18.2) | 0.911 | 644 | 0.903 (−2.33, 4.14) | 0.585 | |
| MCPP | Visit 1 | 646 | −2.19 (−5.39, 1.12) | 0.194 | 638 | 0.88 (−3.63, 5.6) | 0.708 | 646 | 1.7 (0.808, 2.59) | 0.000 |
| Visit 3 | 646 | −1.13 (−4.77, 2.66) | 0.556 | 638 | 1.86 (−2.92, 6.87) | 0.454 | 646 | 0.834 (−0.135, 1.8) | 0.094 | |
| MECPP | Visit 1 | 649 | −9.21 (−22.2, 5.92) | 0.221 | 641 | 16.3 (−6.85, 45.1) | 0.185 | 649 | 1.96 (−2.33, 6.24) | 0.372 |
| Visit 3 | 649 | −7.42 (−22.4, 10.4) | 0.392 | 641 | 16.6 (−8.11, 47.9) | 0.208 | 649 | 1 (−3.76, 5.76) | 0.680 | |
| MEHHP | Visit 1 | 648 | −6.39 (−16.3, 4.72) | 0.250 | 640 | 11.1 (−5.18, 30.3) | 0.195 | 648 | 0.89 (−2.21, 3.99) | 0.575 |
| Visit 3 | 648 | −3.2 (−14.8, 9.99) | 0.619 | 640 | 10.3 (−6.99, 30.8) | 0.262 | 648 | 0.643 (−2.79, 4.08) | 0.715 | |
| MEHP | Visit 1 | 647 | −1.48 (−6.98, 4.35) | 0.612 | 639 | 0.949 (−6.99, 9.57) | 0.821 | 647 | 0.679 (−0.911, 2.27) | 0.404 |
| Visit 3 | 647 | −0.695 (−7.26, 6.33) | 0.842 | 639 | 2.83 (−6.06, 12.5) | 0.546 | 647 | 0.592 (−1.23, 2.42) | 0.525 | |
| MEOHP | Visit 1 | 646 | −4.23 (−14.2, 6.96) | 0.445 | 638 | 11.3 (−4.68, 30.1) | 0.178 | 646 | 1.3 (−1.75, 4.34) | 0.404 |
| Visit 3 | 646 | −1.23 (−13.1, 12.3) | 0.851 | 638 | 11.5 (−5.81, 32.1) | 0.208 | 646 | 1.05 (−2.39, 4.48) | 0.552 | |
| MEP | Visit 1 | 644 | −9.55 (−20.8, 3.28) | 0.140 | 636 | −14.6 (−29.3, 3.12) | 0.103 | 644 | 2.29 (−1.36, 5.93) | 0.221 |
| Visit 3 | 644 | 1.17 (−12.6, 17.1) | 0.877 | 636 | −8.85 (−25.2, 11.1) | 0.360 | 644 | −1.35 (−5.3, 2.59) | 0.503 | |
| MiBP | Visit 1 | 648 | −2.48 (−14.1, 10.7) | 0.699 | 640 | 2.34 (−14.8, 22.9) | 0.805 | 648 | 0.359 (−3.17, 3.89) | 0.843 |
| Visit 3 | 648 | 0.931 (−12.6, 16.6) | 0.900 | 640 | 9.12 (−10.5, 33) | 0.389 | 648 | 0.953 (−2.98, 4.88) | 0.635 | |
| MHBP | Visit 1 | 435 | −2.13 (−6.26, 2.18) | 0.329 | 433 | 1.84 (−4.78, 8.93) | 0.596 | 435 | 0.685 (−0.606, 1.98) | 0.301 |
| Visit 3 | 435 | 1.37 (−3.85, 6.86) | 0.615 | 433 | 2.05 (−5.29, 9.96) | 0.595 | 435 | 1.75 (0.235, 3.27) | 0.026 | |
| MHiBP | Visit 1 | 437 | −4.74 (−14.1, 5.61) | 0.359 | 435 | 9.08 (−7.27, 28.3) | 0.297 | 437 | −0.356 (−3.47, 2.76) | 0.823 |
| Visit 3 | 437 | −10.6 (−20.4, 0.485) | 0.063 | 435 | 2.42 (−14.1, 22.1) | 0.790 | 437 | 1.85 (−1.62, 5.32) | 0.300 | |
| MECPTP | Visit 1 | 153 | −0.868 (−15.6, 16.4) | 0.916 | 153 | −7.85 (−27.9, 17.8) | 0.518 | 153 | 2.04 (−3.15, 7.24) | 0.447 |
| Visit 3 | 153 | −15.7 (−30.2, 1.97) | 0.089 | 153 | 7.36 (−16.6, 38.2) | 0.585 | 153 | 1.9 (−4.64, 8.43) | 0.573 | |
| MEHHTP | Visit 1 | 153 | −3.01 (−11.7, 6.57) | 0.530 | 153 | −2.6 (−16.4, 13.4) | 0.737 | 153 | 0.541 (−2.51, 3.59) | 0.730 |
| Visit 3 | 153 | −13.1 (−22.3, −2.75) | 0.020 | 153 | 4.19 (−11, 21.9) | 0.612 | 153 | 1.1 (−2.78, 4.98) | 0.583 | |
| MONP | Visit 1 | 153 | 0.687 (−6.36, 8.26) | 0.854 | 153 | −0.835 (−11.2, 10.8) | 0.883 | 153 | 0.655 (−1.65, 2.96) | 0.581 |
| Visit 3 | 153 | 0.989 (−6.59, 9.18) | 0.806 | 153 | −5 (−14.7, 5.8) | 0.358 | 153 | −0.263 (−2.84, 2.31) | 0.842 | |
| T3 | T4 | Testosterone a | ||||||||
| N | %Δ (95% CI) | P | N | %Δ (95% CI) | P | N | %Δ (95% CI) | P | ||
| MBP | Visit 1 | 650 | 5.42 (0.108, 10.7) | 0.047 | 651 | 4.94 (−0.208, 10.1) | 0.062 | 648 | 11.5 (−5.12, 31.1) | 0.188 |
| Visit 3 | 650 | 7.17 (1.47, 12.9) | 0.015 | 651 | 4.2 (−1.36, 9.76) | 0.141 | 648 | 7.03 (−10.1, 27.4) | 0.446 | |
| MBzP | Visit 1 | 645 | 1.93 (−0.552, 4.42) | 0.129 | 646 | 2.58 (0.181, 4.98) | 0.037 | 643 | 4.39 (−3.17, 12.5) | 0.265 |
| Visit 3 | 645 | 2.51 (−0.207, 5.23) | 0.072 | 646 | 1.13 (−1.51, 3.78) | 0.403 | 643 | −2.33 (−10.2, 6.24) | 0.584 | |
| MCNP | Visit 1 | 641 | 0.929 (−0.342, 2.2) | 0.154 | 642 | 0.482 (−0.762, 1.73) | 0.449 | 639 | 2.62 (−1.33, 6.73) | 0.199 |
| Visit 3 | 641 | 0.829 (−0.494, 2.15) | 0.221 | 642 | 0.443 (−0.866, 1.75) | 0.508 | 639 | −3.34 (−7.25, 0.734) | 0.109 | |
| MCOP | Visit 1 | 642 | 5.78 (1.97, 9.59) | 0.003 | 643 | 4.66 (0.978, 8.34) | 0.014 | 640 | 16.5 (3.83, 30.7) | 0.010 |
| Visit 3 | 642 | 4.53 (0.284, 8.79) | 0.038 | 643 | 3.16 (−0.99, 7.3) | 0.138 | 640 | −7.77 (−19, 5) | 0.223 | |
| MCPP | Visit 1 | 644 | 1.91 (0.69, 3.12) | 0.003 | 645 | 2.07 (0.896, 3.24) | 0.001 | 642 | 0.156 (−3.52, 3.98) | 0.935 |
| Visit 3 | 644 | 1.86 (0.572, 3.15) | 0.005 | 645 | 1.59 (0.351, 2.84) | 0.013 | 642 | −3.25 (−6.99, 0.637) | 0.102 | |
| MECPP | Visit 1 | 647 | 9.26 (3.4, 15.1) | 0.002 | 648 | 2.4 (−3.32, 8.12) | 0.412 | 645 | −3.08 (−19, 15.9) | 0.732 |
| Visit 3 | 647 | 12.4 (6.04, 18.8) | 0.000 | 648 | 2.33 (−3.9, 8.57) | 0.464 | 645 | −15.6 (−30.7, 2.71) | 0.092 | |
| MEHHP | Visit 1 | 646 | 4.18 (−0.056, 8.41) | 0.055 | 647 | −0.128 (−4.24, 3.98) | 0.951 | 644 | 2.06 (−10.3, 16.1) | 0.757 |
| Visit 3 | 646 | 6.15 (1.57, 10.7) | 0.009 | 647 | 0.538 (−3.93, 5.01) | 0.814 | 644 | −8.32 (−20.4, 5.55) | 0.229 | |
| MEHP | Visit 1 | 645 | 0.557 (−1.61, 2.73) | 0.616 | 646 | 0.773 (−1.34, 2.89) | 0.475 | 643 | 3.57 (−3.09, 10.7) | 0.303 |
| Visit 3 | 645 | 2.66 (0.247, 5.07) | 0.032 | 646 | 1.01 (−1.36, 3.38) | 0.406 | 643 | −1.72 (−8.82, 5.92) | 0.650 | |
| MEOHP | Visit 1 | 644 | 5.16 (1.01, 9.32) | 0.016 | 645 | 0.83 (−3.21, 4.87) | 0.687 | 642 | 3.45 (−8.84, 17.4) | 0.600 |
| Visit 3 | 644 | 6.97 (2.41, 11.5) | 0.003 | 645 | 1.71 (−2.76, 6.18) | 0.454 | 642 | −7.41 (−19.6, 6.58) | 0.286 | |
| MEP | Visit 1 | 642 | 3.21 (−1.79, 8.21) | 0.211 | 643 | 1.33 (−3.5, 6.15) | 0.591 | 640 | −11.4 (−23.9, 3.2) | 0.122 |
| Visit 3 | 642 | 3.22 (−2.07, 8.51) | 0.235 | 643 | −1.38 (−6.53, 3.77) | 0.601 | 640 | −18 (−30.3, −3.57) | 0.018 | |
| MiBP | Visit 1 | 646 | 3.63 (−1.22, 8.48) | 0.144 | 647 | −1.22 (−5.91, 3.46) | 0.609 | 644 | 2.91 (−11.2, 19.2) | 0.703 |
| Visit 3 | 646 | 5.51 (0.207, 10.8) | 0.043 | 647 | 0.087 (−5.07, 5.25) | 0.974 | 644 | −5.81 (−20, 10.8) | 0.472 | |
| MHBP | Visit 1 | 435 | 1.79 (0.036, 3.55) | 0.048 | 435 | 0.127 (−1.59, 1.85) | 0.886 | 436 | 4.88 (−0.275, 10.3) | 0.067 |
| Visit 3 | 435 | 1.18 (−0.741, 3.11) | 0.231 | 435 | 0.92 (−1.06, 2.9) | 0.364 | 436 | 4.45 (−1.54, 10.8) | 0.152 | |
| MHiBP | Visit 1 | 437 | 4.78 (0.552, 9) | 0.029 | 437 | −1.56 (−5.7, 2.58) | 0.461 | 438 | 6.36 (−5.88, 20.2) | 0.325 |
| Visit 3 | 437 | 5.03 (0.482, 9.57) | 0.033 | 437 | −0.286 (−4.85, 4.28) | 0.902 | 438 | −5.04 (−17.1, 8.77) | 0.457 | |
| MECPTP | Visit 1 | 153 | 3.99 (−3.01, 11) | 0.272 | 153 | 4.45 (−1.83, 10.7) | 0.174 | 153 | 5.24 (−14.2, 29.1) | 0.627 |
| Visit 3 | 153 | 0.63 (−7.54, 8.8) | 0.881 | 153 | −3.14 (−10.6, 4.28) | 0.413 | 153 | −2.31 (−23.6, 25) | 0.853 | |
| MEHHTP | Visit 1 | 153 | 2.96 (−1.2, 7.12) | 0.173 | 153 | 2.04 (−1.71, 5.79) | 0.295 | 153 | 2.61 (−9.05, 15.8) | 0.678 |
| Visit 3 | 153 | 1.56 (−3.34, 6.46) | 0.537 | 153 | −1.27 (−5.75, 3.22) | 0.584 | 153 | −3.02 (−16.3, 12.4) | 0.686 | |
| MONP | Visit 1 | 153 | 3.98 (0.889, 7.08) | 0.017 | 153 | 1.07 (−1.75, 3.89) | 0.461 | 153 | 1.49 (−7.24, 11) | 0.750 |
| Visit 3 | 153 | 1.58 (−1.73, 4.89) | 0.357 | 153 | 1.08 (−1.94, 4.1) | 0.490 | 153 | −7.72 (−16.3, 1.73) | 0.116 | |
| Progesterone/E3 a | T3/T4 | |||||||||
| N | %Δ (95% CI) | P | N | %Δ (95% CI) | P | |||||
| MBP | Visit 1 | 652 | −1.68 (−16.2, 15.4) | 0.836 | 649 | 0.038 (−6.09, 6.16) | 0.990 | |||
| Visit 3 | 652 | 16.0 (−3.14, 39) | 0.109 | 649 | 2.56 (−4.09, 9.21) | 0.452 | ||||
| MBzP | Visit 1 | 648 | −0.193 (−7.25, 7.4) | 0.959 | 644 | −0.77 (−3.62, 2.08) | 0.597 | |||
| Visit 3 | 648 | 7.18 (−1.69, 16.9) | 0.118 | 644 | 1.51 (−1.68, 4.69) | 0.355 | ||||
| MCNP | Visit 1 | 643 | −4.37 (−8.09, −0.491) | 0.029 | 640 | 0.345 (−1.14, 1.83) | 0.649 | |||
| Visit 3 | 643 | −3.08 (−7.25, 1.29) | 0.167 | 640 | 0.483 (−1.09, 2.06) | 0.549 | ||||
| MCOP | Visit 1 | 644 | −5.61 (−16, 6.1) | 0.335 | 641 | 1.48 (−2.95, 5.91) | 0.513 | |||
| Visit 3 | 644 | −14.0 (−25.3, −1.02) | 0.037 | 641 | 1.33 (−3.73, 6.39) | 0.607 | ||||
| MCPP | Visit 1 | 646 | −2.66 (−6.29, 1.11) | 0.166 | 643 | 0.001 (−1.42, 1.42) | 0.999 | |||
| Visit 3 | 646 | −1.80 (−5.87, 2.46) | 0.403 | 643 | 0.127 (−1.4, 1.65) | 0.871 | ||||
| MECPP | Visit 1 | 649 | −12.1 (−26.4, 4.94) | 0.156 | 646 | 6.96 (0.22, 13.7) | 0.045 | |||
| Visit 3 | 649 | −2.13 (−19.9, 19.6) | 0.834 | 646 | 8.9 (1.49, 16.3) | 0.020 | ||||
| MEHHP | Visit 1 | 648 | −2.59 (−14.4, 10.8) | 0.690 | 645 | 4.75 (−0.121, 9.62) | 0.058 | |||
| Visit 3 | 648 | 3.26 (−10.7, 19.4) | 0.666 | 645 | 4.60 (−0.744, 9.94) | 0.094 | ||||
| MEHP | Visit 1 | 647 | −1.87 (−8.13, 4.81) | 0.575 | 644 | −0.147 (−2.65, 2.36) | 0.909 | |||
| Visit 3 | 647 | 4.32 (−3.47, 12.7) | 0.287 | 644 | 0.953 (−1.89, 3.79) | 0.512 | ||||
| MEOHP | Visit 1 | 646 | −4.30 (−15.7, 8.61) | 0.497 | 643 | 4.66 (−0.123, 9.44) | 0.058 | |||
| Visit 3 | 646 | 3.90 (−10.2, 20.2) | 0.607 | 643 | 4.49 (−0.843, 9.82) | 0.101 | ||||
| MEP | Visit 1 | 644 | −10.3 (−23, 4.37) | 0.161 | 641 | 2.03 (−3.74, 7.79) | 0.492 | |||
| Visit 3 | 644 | −8.77 (−22.8, 7.83) | 0.284 | 641 | 4.47 (−1.68, 10.6) | 0.157 | ||||
| MiBP | Visit 1 | 648 | 6.64 (−7.85, 23.4) | 0.390 | 645 | 4.26 (−1.31, 9.82) | 0.136 | |||
| Visit 3 | 648 | 6.36 (−9.81, 25.4) | 0.465 | 645 | 5.41 (−0.73, 11.6) | 0.086 | ||||
| MHBP | Visit 1 | 435 | −2.88 (−7.56, 2.04) | 0.250 | 435 | 1.53 (−0.581, 3.65) | 0.159 | |||
| Visit 3 | 435 | 0.298 (−5.39, 6.32) | 0.921 | 435 | 0.12 (−2.28, 2.52) | 0.922 | ||||
| MHiBP | Visit 1 | 437 | −5.93 (−16.5, 5.94) | 0.316 | 437 | 5.43 (0.365, 10.5) | 0.038 | |||
| Visit 3 | 437 | −7.64 (−19.1, 5.43) | 0.242 | 437 | 4.33 (−1.22, 9.88) | 0.130 | ||||
| MECPTP | Visit 1 | 153 | −9.01 (−25.7, 11.5) | 0.369 | 153 | −1.19 (−8.72, 6.34) | 0.759 | |||
| Visit 3 | 153 | 0.896 (−21.9, 30.4) | 0.946 | 153 | 4.73 (−3.92, 13.4) | 0.292 | ||||
| MEHHTP | Visit 1 | 153 | −5.55 (−16.1, 6.37) | 0.354 | 153 | 0.221 (−4.28, 4.72) | 0.924 | |||
| Visit 3 | 153 | −3.52 (−17.1, 12.3) | 0.647 | 153 | 3.3 (−1.92, 8.52) | 0.225 | ||||
| MONP | Visit 1 | 153 | 1.1 (−7.61, 10.6) | 0.814 | 153 | 2.89 (−0.509, 6.28) | 0.106 | |||
| Visit 3 | 153 | 0.68 (−8.98, 11.4) | 0.896 | 153 | 0.328 (−3.27, 3.93) | 0.859 | ||||
All models were adjusted for categorical maternal age, ordinal maternal education, study visit, and specific gravity. P values were derived from an interaction term between study visit and log(phthalate). Boldface type indicates a 95% CI.
Note that 405 and 272 women provided samples at visit 1 (median, 18 wk) and visit 3 (median, 26 wk), respectively.
a
Hormone levels were natural log transformed for all analyses.