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. Author manuscript; available in PMC: 2020 May 10.
Published in final edited form as: J Control Release. 2019 Mar 11;301:54–61. doi: 10.1016/j.jconrel.2019.03.008

Figure 5. Free anti-ICAM-1 antibodies and brain: Intra-venous vs intra-arterial administrations.

Figure 5.

Blood normalized biodistribution of radiolabelled NP 30 minutes after intra-venous injection (IV) or intra-arterial administration (IA) in TNFα injured animals: (A) lungs and (B) brain. Please note the logarithmic scale. ** (p<0.01, IgG vs anti-ICAM-1); # (p<0.05, IV vs IA) one-way ANOVA (Bonferroni post-hoc analysis); * (*p<0.05, Mann-Whitney) for the ISI. Mean±SD. NPs: n=3 (IgG and anti-ICAM-1, IV); n=3–5 (IgG and anti-ICAM-1, respectively, IA.