Table 3.
A table summarizing the investigations done and the disease entities excluded while evaluating this patient with pancytopenia and chronic liver disease
Diseases excluded | Presentation and investigations for exclusion |
---|---|
Visceral leishmaniasis | Negative LD bodies, rk-39 ELISA |
Dengue | Negative NS1 IgG and IgM antibodies |
Hepatitis B and C | Negative anti-HBC Ab and HbsAg |
HIV | Negative anti-HIV Ab |
Celiac disease | No GI complaints and negative anti-TTG Ab |
Systemic lupus erythematosus and rheumatoid arthritis | No skin rash, joint complaints, and negative ANA |
EBV | Negative anti-EBV VCA |
HSV | Negative serology and no skin lesions |
Malaria | Negative peripheral blood smears |
Tuberculosis | Negative sputum, urine and blood AFB, negative tuberculin skin test, and no chest X-ray findings |
CMV | Negative PP65 |
Malignancy | Negative blood smear, ascitic tap transudative with normal cytology, negative lymph node biopsy, CT abdomen revealed no signs of malignancy |
Scrub typhus | Negative Weil-Felix and immunochromatographic tests, no rash |
Leptospirosis | Negative IgM serology or macro agglutination test |
Parvo virus B19 | Negative IgM serology |
Wilson disease | Normal serum ceruloplasmin, negative liver biopsy, and normal slit lamp examination |
Hemochromatosis | Negative liver biopsy, no other endocrine, or skin symptoms |
Autoimmune hepatitis | Negative antismooth muscle antibodies, negative liver biopsy |
Glycogen storage disorders | Negative liver biopsy |