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. 2019 May 7;11:4209–4221. doi: 10.2147/CMAR.S194453

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© 2019 Yang et al. This work is published and licensed by Dove Medical Press Limited

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DLX6-AS1 promotes PC cell proliferation, migration, and invasion via miR-497-5p/FZD4/FZD6/Wnt/β-catenin signaling pathway.

Notes: (A) The effect of DLX6-AS1 on FZD4 and FZD6 was determined by dual-luciferase reporter assay. (B) Overexpression of DLX6-AS1 increased the expression of FZD4, FZD6, and β-catenin, whereas knockdown of DLX6-AS1 decreased the expression of FZD4, FZD6, and β-catenin. (C) Overexpression of DLX6-AS1 increased the expression of FZD4, FZD6, and β-catenin, while this increasing effect was abrogated by miR-497-5p mimics. (D) Knockdown of DLX6-AS1 inhibited the expression of FZD4, FZD6, and β-catenin, while this inhibitory effect was abrogated by the overexpression vectors of FZD4 or FZD6. Knockdown of DLX6-AS1 inhibited (E) proliferation, (F) cell cycle, (G) migration, and (H) invasion, and promoted (I) apoptosis of PC cells, while these inhibition or promotion effects of DLX6-AS1 were abrogated by the overexpression vectors of FZD4 or FZD6. Data are presented as mean ± SD. **P<0.01, and ***P<0.001.

Abbreviations: CCK-8, Cell Counting Kit-8; PC, pancreatic cancer.