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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2019 Feb 12;129:27–38. doi: 10.1016/j.yjmcc.2019.01.007

Fig. 5.

Fig. 5.

Med13 is induced by and is important for cardiac responses to hypothyroidism. WT and Med13cKO mice were fed a normal chow (NC) diet or a PTU diet for 16 weeks. A. Ventricular Med13 mRNA expression in WT and Med13cKO mice after 16 weeks on the indicated diet. n =5–6/group B. Ventricular Med13 protein expression in WT and Med13cKO mice after 16 weeks on the indicated diet. C. Heart weight to body weight ratio (HW/BW; mg/g) after four weeks on the indicated diet. n =6–10/group. D. Ejection fraction of WT or Med13cKO mice, as determined by serial echocardiogram at 4 weeks, 8 weeks, 12 weeks, and 16 weeks following the start of the indicated diet. n =6–10/group. E. Ventricular mRNA expression of known TH-regulated, hypertrophic markers in WT and Med13cKO mice following 16 weeks on the indicated diet. n =5–6/group. *p < .05 diet-specific comparison. # < 0.05 genotype-specific comparison, Two way ANOVA, Tukey’s multiple comparisons test. Data represent mean ± SEM.