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. 2019 May 3;10:468. doi: 10.3389/fphar.2019.00468

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Copyright © 2019 Carcolé, Zamanillo, Merlos, Fernández-Pastor, Cabañero and Maldonado.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acute and chronic treatments with E-52862 improved the cognitive deficits induced by MIA injection. (A) Saline or MIA-injected mice treated with vehicle or E-52862 (20 mg/kg, twice daily during 25 days) were evaluated for recognition memory 15 days after the intra-knee injection in the novel object recognition test (NORT). (B) Mice with osteoarthritis pain treated with vehicle showed decreased discrimination index indicating a memory impairment. Acute and chronic treatment with E-52862 reversed the cognitive deficits induced by MIA. (C) Animals revealed similar total exploration times regardless of the surgery or the treatment. Data are expressed as mean ± SEM (n = 6–8 animals per group). ^∗p < 0.05, ^∗∗∗p < 0.001 vs. MIA-vehicle (1-way ANOVA followed by Fisher least significant difference test). MIA, monosodium iodoacetate; SEM, standard error of the mean.