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. 2019 May 3;10:422. doi: 10.3389/fgene.2019.00422

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Copyright © 2019 Lei, Chen, Zhang, Yang, Xu, Cao, Zhang and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TALE treatment of neural progenitor cells causes neuronal differentiation. (A) IB detection of protein level of the epigenetic modification enzymes in neurospheres without (DMSO) and with TALE (TALE) treatment. β-Act: loading control. (B) Immunofluorescence (IF) detection of the markers for neural stemness, Sox1 and Pax3, in neurospheres without and with TALE treatment. (C) IF detection of the markers for neuron cells, Tubb3 and Map2, in neurospheres without and with TALE treatment. In (B,C), cell nuclei were counterstained with DAPI.