Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 3;10:422. doi: 10.3389/fgene.2019.00422

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Lei, Chen, Zhang, Yang, Xu, Cao, Zhang and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

EZH2 knockdown induces neuronal differentiation in SW480 cells and represses signals promoting malignancy. (A) Knockdown of EZH2 generated a significant neuronal phenotype in SW480 cells, as compared with knockdown either of HDAC1, HDAC3, LSD1, or of DNMT1. (B) Heatmap based on a gene expression profiling assay showing expression changes of neuronal genes in cells without (shCtrl) or with EZH2 knockdown (shEZH2). (C–E) The enriched disease terms (C), Reactome pathway terms (D) and GO terms (E) for differentially expressed genes from the profiling assay. (F) IB assay showing the effect of EZH2 knockdown on the expression of neuron-specific proteins and proteins that are involved in promoting malignanacy. β-ACT was used as a loading control.