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. 2019 May 3;10:464. doi: 10.3389/fphys.2019.00464

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Copyright © 2019 Liu, Zhao, Zhang, Li, Shen, Liu, Jiang, Luo, Wang, Che and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Renal dysfunction and fibrosis after ischemic acute kidney injury in rats. After clamped the right renal pedicle for 40 min, the level of serum creatinine (Scr) was detected by automatic biochemistry analyzer (A). The fibrosis was evaluated by pathological section and Masson staining (B). The relative area of collagen fiber was counted by Image J software (C). NS, no significance, ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001 vs. Control; ^###P < 0.001 vs. AKI 1W.