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Interference with Cyr61 expression reduced the transcription of senescence related factors in renal fibroblasts. These factors (P53, P21, and Rb) were detected by real time PCR. ∗P < 0.05 and ∗∗P < 0.01 vs. control group; #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. activated group.
