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. 2019 Feb 14;68(5):623–629. doi: 10.1097/MPG.0000000000002308

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

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Effects of ketoprofen on the immature intestinal mucosa. A, Inhibition of PGE2 production was evaluated in the presence of 2 concentrations of ketoprofen (mean ± SEM, ^∗∗∗P < 0.005). B, qPCR analysis of transcript levels for representative markers of mucosal homeostasis categories after 48 hours of culture in the presence of 10 μM ketoprofen. C, For comparison, markers expressed relative to the same housekeeping genes in response to 1 μM indomethacin under similar conditions. qPCR data are expressed as ratios of treated over untreated segments (Log2 scale). Values from 6 independent biological samples (mean ± SEM). ^∗P < 0.05 (^#P < 0.06) versus corresponding untreated control segments.