TABLE 1.
qPCR analysis of the effects of H2S released on the expression of representative markers for distinct mucosal homeostasis categories in ketoprofen responders and non-responders
| Responders | Non-responders | |||
| Genes | Ratio ATB/Keto* | P | Ratio ATB/Keto* | P |
| Oxidoreductase activity | ||||
| CYP3A4 | 1.00 ± 0.44 | 0.9907 | 2.07 ± 2.19 | 0.4866 |
| DUOX2 | 1.61 ± 0.34 | 0.0900 | 0.43 ± 0.46 | 0.1616 |
| NOS2 | 1.60 ± 0.27 | 0.0596 | 0.33 ± 0.24 | 0.0418† |
| SOD2 | 1.22 ± 0.16 | 0.1374 | 0.78 ± 0.29 | 0.3251 |
| Oxidative phosphorylation | ||||
| ATP5G1 | 1.24 ± 0.40 | 0.4064 | 0.83 ± 0.10 | 0.0909 |
| NDUFA9 | 1.21 ± 0.41 | 0.4644 | 0.93 ± 0.44 | 0.8155 |
| Inflammatory response | ||||
| CXCL14 | 1.38 ± 0.07 | 0.0125† | 1.21 ± 0.24 | 0.2636 |
| TFF1 | 1.26 ± 0.13 | 0.0724 | 0.85 ± 0.53 | 0.6710 |
| Permeability | ||||
| CLDN-1 | 1.13 ± 0.44 | 0.6663 | 0.73 ± 0.17 | 0.1134 |
| OCLN | 1.27 ± 0.61 | 0.5276 | 0.91 ± 0.43 | 0.7609 |
*Data are expressed as ratios of ATB-352 over ketoprofen (ATB/Keto)-treated immature intestinal explants in both ketoprofen responder and non-responder groups. Data are expressed as the mean ratio of 3 independent biological samples for each group.
†Denote a statistical difference.