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. 2017 Sep 15;359:1138–1142. doi: 10.1126/science.aaf7447

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© The Author(s) 2017

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Fig. 2 — SEAL-fabricated controlled-release microparticles. Particles are fabricated by (A) heating and pressing polymer between a patterned PDMS base mold and a Teflon surface, (B) transferring these bases to a new substrate and filling them with a model drug of interest, then (C) aligning an array of particle caps with drug-filled bases and briefly applying a low amount of heat to sinter the two layers. SEM images of (D) a single particle, (E) the core of a particle, and (F) a sealed particle. (G) A cross section of a single particle and (H) an array of sealed particles. Optical images of (I) an array of bases, (J) an array of filled particles, and (K) a side view of a single filled particle.