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. 2017 Sep 15;359:1138–1142. doi: 10.1126/science.aaf7447

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© The Author(s) 2017

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Fig. 4 — Ovalbumin (OVA) vaccination and storage stability. (A) Longitudinal geometricmean antibody titers and (B) peak antibody titers achieved by mice treated with a single injection of OVA-containing particles or two bolus injections of OVA in solution (n = 5 mice). All peak titer groups were significantly different from those of the control group receiving only methyl cellulose (MC; P < 0.001), but significance markers are not shown for clarity. All other differences are indicated by *P < 0.05 and **P < 0.01.These results show that a single injection of core-shell particles can induce an immune response that is not only noninferior to two dose-matched boluses, but also noninferior to two boluses with double the cumulative dose. (C) Core-shell particles stored desiccated for 30 days at 4°C release the same amount of ELISA-reactive OVA as freshly prepared particles (n = 4 particles). Error bars indicate standard error of the geometric mean in (A) and (B) and standard error of the mean in (C).