Skip to main content
. 2019 May 8;39(19):3752–3769. doi: 10.1523/JNEUROSCI.2070-18.2019

Figure 9.

Figure 9.

The effects of Emapunil depend on TSPO expression. A, Cytotoxicity measured by adenylate kinase release (ToxiLight luminescence) in differentiated LUHMES cells treated with either TSPO or control siRNA. Experimental groups: DMSO, 10 μm rotenone, 5 μm Emapunil, 10 μm rotenone plus 5 μm Emapunil. Two-way ANOVA: F(3,54) = 3.365, p = 0.0251. **p < 0.005; ***p < 0.001; Tukey post hoc test. B, Cytotoxicity (ToxiLight luminescence assay) in differentiated LUHMES cells with increasing rotenone concentrations. One-way ANOVA, in between-group difference: p < 0.0001. ***p < 0.001 (Tukey post hoc test). C, qPCR analysis of spliced XBP1s/unspliced XBP1 in differentiated LUHMES cells treated with TSPO or control siRNA. Experimental groups as in A. Two-way ANOVA: F(3,82) = 6.458, p = 0.0006. **p < 0.005; ***p < 0.001; Tukey post hoc test. n.s. = not significant.