Table S2.

Baseline characteristics of patients with a decreased intestinal barrier function

Age years	M/F	Ethn	Renal disease	CVD	DM	Time on dialysis months	Veg diet	PPI	PO4-binder	K – binder	F. praus copies/ng input gDNA	Eubact. Rect. copies/ng input gDNA	Roseburia spp. copies/ng input gDNA	BCoAT copies/ng input gDNA	CRP mg/l	IL-6 pg/ml	D-lactate mmol/l
69	M	Cauc	Glomerulo-pathy	No	No	N.A.	No	No	Yes	No	547,389	4471	2	4862	47.3	14.3	0.14
62	M	Asian	FSGS	No	No	10	No	Yes	Yes	No	349,171	2883	0	353	19	8.0	0.38
40	F	Cauc	Glomerulo-phaty	No	No	24	No	Yes	Yes	No	258,156	4434	9	1778	2.2	3.0	0.23
39	M	Black	Reno-vascular	Yes	No	72	No	No	No	No	82,416	168,575	56	40,568	0.8	1.6	0.15
62	M	Med	ADPKD	No	No	48	No	Yes	Yes	No	709,905	38,521	34	5530	2.4	4.6	0.13
77	F	Caus	Reno-vascular	Yes	No	96	No	Yes	Yes	No	578,255	7150	298	5873	1.1	3.8	0.24
66	M	Cauc	Hyper-oxaluria	No	No	112	No	No	Yes	No	1450	0	0	409	2.3	10.1	1.2
61	F	Cauc	ADPKD	No	No	24	No	No	Yes	Yes	103,497	64,107	34	10,558	0.5	1.9	0.20
38	M	Black	Reno-vascular	Yes	No	12	No	Yes	Yes	Yes	99,178	1646	7	89	2.3	1.7	0.1

Note: Characteristics of patients with elevated D-lactate levels.

Abbreviations : M, male; F, female, Ethn, ethnicity; Cauc, Caucasian; FSGS, focal segmental glomerulosclerosis; ADPKD, autosomal dominant polycystic kidney disease; veg diet, vegetarian diet; CVD, cardiovascular disease; DM, diabetes mellitus; PPI, proton pump inhibitor; P04, phosphate; K, potassium; Med, Mediterranean; N.A., not applicable.