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. 2019 May 10;14(5):e0215607. doi: 10.1371/journal.pone.0215607

Fig 2. Optimization of PRS Regimens IV and V.

Fig 2

(A) Lung burdens of M. tuberculosis in 10 groups of mice were determined after treatment 5 days per week for 3 weeks with PRS Regimen IV (top left) or PRS Regimen V (top right); the individual drugs were administered in high dose (H), middle dose (M) or low dose (L) as indicated below the horizontal axis. Sham-treated mice or mice treated with either the Standard Regimen (SR) or dose-optimized PRS Regimen II (PRS II) served as controls. The Standard Regimen comprised INH, RIF, EMB and PZA at 25, 10, 100 and 150 mg/kg, respectively. PRS Regimen II comprised CFZ, BDQ, PZA and EMB at 25, 30, 450 and 100 mg/kg, respectively. For PRS Regimen IV, the high doses for CFZ, BDQ, PZA and AC were 25, 50, 450 and 600–150 mg/kg, respectively. For PRS Regimen V, the high doses for CFZ, BDQ, PZA and DLM were 25, 50, 450 and 7.5 mg/kg, respectively. The middle dose of each drug was 1/3rd that of the high dose and the low dose was 1/3rd that of the middle dose. (B) Drug-dose efficacy response surface shown as drug-drug doses on the x- and z-axes and the projected lung log10 CFU on the y-axis.