Table 2. Screening of combinatorial drugs in macrophage model of M. tuberculosis infection.

	Screening test	Iteration #1	Iteration #2	Iteration #3A	Iteration #3B	Iteration #3C
Effect levelsa	2	3	3	5	5	3
Test runsb	150	102	155	75	75	82
Drugsc	AC	AC	AC	AC	AC	AC
	BDQ	BDQ	BDQ	BDQ	BDQ	BDQ
	CFZ	CFZ	CFZ	CFZ	CFZ	CFZ
	DLM	DLM	DLM	DLM	DLM	DLM
	RIF	RIF	RIF	RIF	RIF	RIF
	SQ109	SQ109	SQ109	SQ109	SQ109	SQ109
	PA824	PA824	PA824	PA824		PA824
	PZA	PZA	PZA	PZA
	EMB	EMB	EMB
	PAS	PAS
	PRS	PRO
	CYS
	INH
	LZD
	MXF

^aScreening test was conducted at individual drug concentration that yielded 0% or 10% of the maximal inhibition to the IPTG-induced green fluorescence signal. Iteration #1 was conducted at individual drug concentration that gave 0% or 10% of the maximal inhibition level and one-half of the concentration that gave 10% of the maximal inhibition level. Iteration #2 was done at 0% or 15% effect levels and one-half of the concentration that gave 15% of the maximal inhibition level. Iterations #3A and 3B were conducted at 0% or 20% effect level and two-thirds, one-half or one-fourth of the concentration that gave 20% of the maximal inhibition level. Iteration #3C was conducted at 0% or 15% effect levels and one-half of the concentration that gave 15% of the maximal inhibition level.

^bNumber of combinatorial drug test runs in each experiment.

^cList of drugs tested at screening and each stage of iterations.