Table 1.

Variables considered in RP2 prediction

Categories	Names
Dosimetric information (5)	Mean_Lung_Dose, Maximum_Lung_Dose, $V_5$, $V_{13}$, $V_{20}$
Clinical factors (13)	Smoking, COPD, Chemo, Gender, Adenocarcinoma, Squamous cell carcinoma
	Large cell carcinoma, Poorly differentiated carcinomas, Stage, Age, GTV, KPS,
	Ratio of weight change
Levels of 30 cytokines measured at pretreatment, 2‐week and 4‐week during the treatment (30 + 30 + 30)	EGF, eotaxin, fractalkine, G‐CSF, GM‐CSF, IFN‐γ, IL‐10, IL‐12p40, IL‐12p70,
	IL‐13, IL‐15, IL‐17, IL‐1α, IL‐1β, IL‐1ra, IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8,
	IP‐10, MCP‐1, MIP‐1α, MIP‐1β, sCD40L, TGF‐α, TNF‐α , VEGF, TGF‐β1
miRNAs (62)	Let‐7a‐5p, miR‐100‐5p, miR‐106b‐5p, miR‐10b‐5p, miR‐122‐5p, miR‐124‐3p,
	miR‐125b‐5p, miR‐126‐3p, miR‐134, miR‐143‐3p, miR‐146a‐5p, miR‐150‐5p,
	miR‐155‐5p, miR‐17‐5p, miR‐17‐3p, miR‐18a‐5p, miR‐192‐5p, miR‐195‐5p,
	miR‐19a‐3p, miR‐19b‐3p, miR‐200b‐3p, miR‐200c‐3p, miR‐205‐5p, miR‐21‐5p,
	miR‐210, miR‐221‐3p, miR‐222‐3p, miR‐223‐3p, miR‐224‐5p, miR‐23a‐3p,
	miR‐25‐3p, miR‐27a‐3p, miR‐296‐5p, miR‐29a‐3p, miR‐30d‐5p, miR‐34a‐5p,
	miR‐375, miR‐423‐5p, miR‐574‐3p, miR‐885‐5p, miR‐92a‐3p, let‐7c, miR‐10a‐5p,
	miR‐128, miR‐130b‐3p, miR‐145‐5p, miR‐148a‐3p, miR‐15a‐5p, miR‐193a‐5p,
	miR‐26b‐5p, miR‐30e‐5p, miR‐374a‐5p, miR‐7‐5p, miR‐103a‐3p, miR‐15b‐5p,
	miR‐191‐5p, miR‐22‐3p, miR‐24‐3p, miR‐26a‐5p, miR‐20a‐5p, miR‐93‐5p, miR‐16‐5p
SNPs (60)	Rs3857979(BMP1), Rs4988044 (ATM), Rs1800587(IL1A), Rs17561(IL1A),
	Rs2070874(IL4), Rs1801275(IL4R), Rs4073(CXCL8), Rs2234671(CXCR1),
	Rs1800896(IL10), Rs3135932(IL10RA), Rs1800872(IL10), Rs11556218(IL16),
	Rs4760259(GLI1), Rs1799983(NOS3), Rs689470(PTGS2), Rs12102171(SMAD3),
	Rs6494633(SMAD3),Rs4776342(SMAD3),Rs11615(ERCC1), Rs609261(ATM),
	Rs12906898(SMAD6), Rs7227023(SMAD7), Rs7333607(SMAD9), Rs664143(ATM),
	Rs4803455(TGFB1), Rs1061622(TNFRSF1B), Rs664677(ATM), Rs20417(PTGS2),
	Rs373759(ATM), Rs189037(ATM), Rs12456284(SMAD4), Rs1800057(ATM),
	Rs3212961(ERCC1), Rs3212948(ERCC1), Rs238406(ERCC2), Rs12917(MGMT),
	Rs17655(ERCC5), Rs1047768(ERCC5), Rs12913975(SMAD6), Rs1805794(NBN),
	Rs1625895(TP53), Rs1042522(TP53), Rs25489(XRCC1), Rs9293329(XRCC4),
	Rs1800469(B9D2&TGFB1), Rs2075685(TMEM167A&XRCC4), Rs25487(XRCC1),
	Rs1800795(IL6), Rs1799796(XRCC3), Rs1800468(B9D2&TGFB1),
	Rs1478486(XRCC4), Rs2228000(XPC), Rs2228001(XRC), Rs3218384(XRCC2)
	Rs1799793(ERCC2), Rs1803965(MGMT), Rs2279744(MDM2), Rs2308321(MGMT),
	Rs3218536(XRCC2), Rs2834167(IL10RB), Rs3212986(ERCC1)