Fig. 1.

Effects of prolonged cocaine self-administration in nonhuman primate white matter fiber tracts. Shown are representative color-transformed autoradiograms of [³H]PKIII95 binding to the microglial TSPO in coronal sections at the level of the precommissural striatum in brains of monkeys following 15 months of exposure to food reward (left panel) or cocaine self-administration (0.3 mg/kg/injection; 30 reinforcers per session) (right panel). [³H]PKIII95 binding site densities were selectively elevated in white, but not gray matter. GM, gray matter; WM, white matter