Table 1.
Patients and treatment characteristics.
| Global series (n = 14) | 1.3 mg/m2 dose (n = 7) | 1.5 mg/m2 dose (n = 7) | |
|---|---|---|---|
| Median age (range) | 36 (24–71) | 31 (24–71) | 53 (28–68) |
| Sex (M/F) | 7 (50%)/7 (50%) | 4 (57%)/3 (43%) | 3 (43%)/4 (57%) |
| ECOG PS - 0 - 1 |
9 (62%) 5 (38%) |
5 (71%) 2 (29%) |
4 (57%) 3 (43%) |
| Grade - 1 - 3 |
11 (79%) 3 (21%) |
7 (100%) 0 (0%) |
4 (57%) 3 (43%) |
| Location - Thigh - Leg - Buttock |
10 (71%) 3 (21%) 1 (7%) |
6 (86%) 0 (0%) 1 (14%) |
4 (57%) 3 (43%) 0 |
| Median size mm. (range) | 130 (70–200) | 130 (30–170) | 110 (57–200) |
| Depth - Deep - Superficial |
14 (100%) 0 |
7 (100%) 0 |
7 (100%) 0 |
| Radiotherapy dose - 45 G - 50 Gy |
13 (93%) 1 (7%) |
7 (100%) 0 |
6 (86%) 1 (14%) |
| Surgery - Yes - No (n = 2) |
12 (86%) 2 (14%)a |
6 (86%) 1 (14%) |
6 (86%) 1 (14%) |
| Surgical margin - Free - Positive |
7 (58%) 5 (42%) |
4 (67%) 2 (33%) |
3 (50%) 3 (50%) |
| CHOP rearrangement - Positive - Not available |
12 (86%) 2 (14%)b |
6 (86%) 1 (14%) |
6 (86%) 1 (14%) |
a
2 patients did not undergo surgery, one because developed metastatic disease during neoadjuvant therapy and one because developed a sepsis due to central venous catheter infection and was treated by definitive RT.
b
2 not evaluable for limited material on the biopsy and lack of residual tumor on the surgical specimen.