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. 2019 May 10;9:7193. doi: 10.1038/s41598-019-43760-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Efficacy of QS1189 in cells with acquired resistance to venetoclax. (a) Parental and venetoclax-resistant cells were treated with venetoclax at the indicated doses for 72 h. Cell viability was measured using the MTT assay. (b) Basal levels of pro- and anti-apoptosis bcl-2 family proteins in parental and venetoclax-resistant cells were analysed by immunoblotting. (c) Maver-1/VR-1 and Maver-1/VR-2 cells were stably transduced with lentivirus expressing shBcl-xL. Knockdown of Bcl-xL was confirmed by immunoblotting. (d) shBcl-xL-infected cells were treated with venetoclax for 72 h. Cell viability was assessed by MTT assay. (e) Cell viability was assessed by MTT analysis of parental and venetoclax-resistant cells treated with QS1189 for 72 h. (f ) Cells were treated with 1 μM QS1189 for 6 h. The indicated protein levels were analysed by immunoblotting.