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. 2019 May 10;9:7188. doi: 10.1038/s41598-019-43658-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological analysis of optic nerve regeneration with anterograde tracer at one and four weeks after ONC in wild-type (WT) and CRMP2 KI mice. (A) Longitudinal sections of optic nerves after tracer injection in indicated samples. (B) Higher magnification images of the indicated area in (A). Scale bar in (A) = 500 µm and (B) = 100 µm. (C) Quantification of regenerating axons at indicated distances beyond the crush site in optic nerves in comparison with WT and CRMP2 KI mice (n = 5 mice for each genotype). **p < 0.01, ****p < 0.0001.