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. 2019 May 10;9:7248. doi: 10.1038/s41598-019-43493-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lesion of Y1R-expressing spinal neurons reduces the severity of neuropathic pain. (A,C,E) Intrathecal NPY-saporin (750 ng or 1,000 ng) reduced the development of (A) mechanical hypersensitivity to von Frey filaments (F_2,20 = 5.516, P = 0.01), (C) cold response duration during acetone evaporation (F_2,20 = 9.889, P = 0.001), and (E) mechanical response duration to blunt pin (F_2,20 = 13.43, P = 0.0002), compared to intrathecal Blank-saporin. Repeated Measures Two-way ANOVA + Bonferonni. (B,D,F) Area Under the Curve (AUC) analyses for days 3–17 (P < 0.05 for all panels) and 21–54, respectively. One-way ANOVA + Bonferonni. N = 6–9 per group. ★P < 0.05 compared to Blank-saporin. Dots represent individual subjects within the analysis. Data represent mean ± SEM.