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. 2019 May 10;9:7203. doi: 10.1038/s41598-019-43591-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ApoExos contain large amounts of unedited Alu sequences. (a) Alu editing is reduced in ApoExos. AEI was calculated as the ratio of inosines to (adenosines + inosines) in positions identified by REDItools as real editing positions (coverage depth ≥10 reads, A to G mismatch frequency ≥1%, located within Alu regions) (*Two-tailed unpaired T test, p = 0.0498, n = 2). (b) ApoExos express 10 times more Alu editing sites. Number of Alu editing sites identified by REDItools across samples according to strict criteria (coverage depth ≥10 reads and A to G mismatch frequency ≥1%) (Two-tailed unpaired T test, ***p = 1.5 × 10⁻³, n = 2).