Table 3.

QTcF by category of post-dose maximum value during the multiple-dose period (a) and extension period (b)

(a)
Parameters (unit)	Category	1 mg N = 27		4 mg N = 24
		n	(%)	n	(%)
QTcF (msec)
Actual value	≤ 450	18	66.7	13	54.2
	> 450 to ≤ 480	4	14.8	6	25.0
	> 480 to ≤ 500	0		1	4.2
	> 500	1	3.7	0
Change from baseline	≤ 30	21	77.8	14	58.3
	> 30 to ≤ 60	2	7.4	4	16.7
	> 60	0		0

(b)
Parameters (unit)	Category	8 mg N = 5		12 mg N = 4
		n	(%)	n	(%)
QTcF (msec)
Actual value	≤ 450	4	80.0	3	75.0
	> 450 to ≤ 480	0		0
	> 480 to ≤ 500	0		0
	> 500	0		0
Change from baseline	≤ 30	4	80.0	3	75.0
	> 30 to ≤ 60	0		0
	> 60	0		0

QTcF Fridericia’s corrected QT