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. 2019 Mar 12;93(4):953–964. doi: 10.1007/s00204-019-02417-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Screening results of the DTP Oncology Set IV measured against parental A431 and its OATP2B1-expressing derivative (A431-2B1). Compounds displaying at least a threefold difference in toxicity (dashed line) between the control and transporter-expressing cells were considered as putative substrates (SR > 3, see inset)