Figure 3.

Exercise improves the ability of FGF21 to induce adiponectin secretion in HFD-induced obese mice. (A) FGF21 stimulates total adiponectin secretion. (B) Fold increase of FGF21-induced total adiponectin secretion. (C) FGF21 increases HMW adiponectin secretion. (D) Fold increase of FGF21-induced HMW adiponectin secretion. Data are presented as the mean ± s.e.m.; n = 7 per group. For A and C, ^aP < 0.05, saline administration vs FGF21 administration. For B and D, ^aP < 0.05 for difference from LFD; ^bP < 0.05 for difference from HFD.