Table 3.

Associations of variables with composite renal function decline events in Japanese patients: differences based on hemoglobin concentration

	Hb
Variables	≥ 12 g/dL		< 12 g/dL
	HR (95% CI)	P value	HR (95% CI)	P value
Na–Cl (< 34 mmol/L)	1.182 (0.801–1.744)	0.400	1.517 (1.089–2.115)	0.014
Male	1.892 (1.120–3.197)	0.017	2.528 (1.808–3.537)	< 0.001
Age (≥ 65 years)	0.776 (0.517–1.165)	0.221	0.918 (0.677–1.245)	0.583
Diabetic nephropathy	1.364 (0.886–2.100)	0.159	1.287 (0.921–1.800)	0.140
ACEIs/ARBs	0.992 (0.650–1.515)	0.971	0.711 (0.493–1.027)	0.069
Serum albumin (g/dL)	0.312 (0.181–0.537)	< 0.001	0.568 (0.375–0.861)	0.008
Systolic blood pressure (≥ 140 mmHg)	1.232 (0.836–1.817)	0.292	1.798 (1.322–2.446)	< 0.001
UACR (≥ 1000 mg/g・Cre)	4.494 (2.909–6.943)	< 0.001	2.889 (2.069–4.034)	< 0.001
CKD stage G4	6.066 (2.432–15.129)	< 0.001	3.537 (1.427–8.764)	0.006
G3b	1.795 (0.696–4.631)	0.226	0.980 (0.370–2.598)	0.968

Composite renal function decline event: any initiation of RRT or 50% decline in eGFR from baseline. All data shown with hazard ratio (95% confidence interval)

DM diabetes mellitus, ACEIs angiotensin-converting enzyme inhibitors, ARBs angiotensin receptor blockers, UACR urine albumin-to-creatinine ratio