Table 2.

Genes whose overexpression can augment the generation of diverse proteins which are paramount to ameliorate healing of cartilaginous tissue

Growth Factors IGF-1, TGF-b, BMPs, FGF-2, GDF-5, VEGF antagonist

Transcription Factors SOX genes (5, 6 and 9) ZNF145

Anti-Inflammatory Cytokines IL10, IL1ra

Mirna MiR-23b, miR-140, miR-181b, miR221, miR-145, miR-335

Other Factors Cell signaling protein iHH, ECM component (COMP), integrin b 1

IGF-1=Insulin-like growth factor-1; TGF-b=Transforming growth factor b; BMPs=Bone morphogenetic proteins; FGF-2; Fibroblast growth factor 2; GDF-5=Growth and differentiation factor 5; VEGF=Vascular endothelial growth factor; SOX=Sex-determining Region Y-related High Mobility Group box; ZNF145=Zinc-finger protein 145; IL10=Interleukin 10; IL1ra=Interleukin 1 receptor antagonist; miRNA=Micro RNA; iHH=Indian hedgehog homolog; ECM=Extracellular matrix; COMP=Cartilage oligomeric matrix protein.