Table 3.
Types of biomaterials used for the different gene transfer vectors currently used in gene therapy for cartilage repair
| Author | Year | Biomaterial Used | Comments |
|---|---|---|---|
| Wang et al (43) | 2008 | PHBHHx | The results of this study demonstrated that PHBHHx is a useful material for cartilage tissue engineering. |
| Chen et al (44) | 2013 | PEI | 3.0-T MRI in vivo tracking of PEI/SPIO-labeled bone marrow-derived mesenchymal stem cells seeded in type II collagen gel on cartilage repair following transplantation is feasible in minipigs. |
| Shafiee (42) | 2016 | PLLA | Cells were seeded onto aligned electrospun PLLA/poly (ε-caprolactone) nanofibrous scaffolds. The aligned nanofibrous hybrid scaffolds could support the proliferation and chondrogenic differentiation of all cell types. |
| Dey et al (45) | 2016 | PEG | The chondrocyte viability in dPGS hydrogels is found to be higher than in pure PEG and alginate-based hydrogels after 21 d. The higher cell viability in the dPGS engineered hydrogels can be explained by the fact that dPGS can interact with different proteins responsible for cell growth and proliferation. |
| Chen et al (40) | 2017 | Chitosan | The combination of photo-crosslinked hydrogel and crizotinib-loaded chitosan microspheres might represent a promising strategy for osteoarthritis treatment. |
| Shi et al (41) | 2018 | Chitosan + PEG | Folate-PEG-CH-DEAE15 nanoparticles are a safe and effective platform for nonviral gene delivery of siRNA, and their potential clinical applications warrant further investigation. |