Table 3.

Factors possibly associated with severe CRS

Characteristic	Grade 1 or 2	≥Grade 3	P value
Case, n	10	7
Clonal BM plasma cells
Mean value, %	18.09	25.44	0.579*
≥10%, n	5	4	0.772†
<10%, n	5	3
Serum M protein
Mean value, g/L	15.79	26.56	0.301*
≥30 g/L, n	1	2	0.323†
<30 g/L, n	9	5
Lactate dehydrogenase
Mean value, U/L	396.70	271.29	0.562*
≥192 U/L, n	3	5	0.092†
<192 U/L, n	7	2
Extramedullary lesions
Present, n	2	3	0.309†
Absent, n	8	4
Hemoglobin
Mean value, g/L	80.50	90.57	0.330*
≥90 g/L, n	1	3	0.116†
<90 g/L, n	9	4
del(17p)
Yes, n	0	3	0.029†
No, n	9	4
BCMA abundance
Mean value, %	80.23	96.77	0.035*
Bone lesions
Yes, n	7	6	0.452†
No, n	3	1
CAR+ cell dose
Mean value, ×106/kg	0.64	0.78	0.549*
≥0.7 × 106/kg, n	3	3	0.585†
<0.7 × 106/kg, n	7	4

^*P value is calculated by t test.

^†P value is calculated by χ² test.