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Positive feedback loop among IL1/NF-κb, IL6/STAT3, and TNF/AP-1 pathways. (A) The positive feedback loop of IL1/NF-κb, IL6/STAT3, and TNF/AP-1 pathways. The red colored genes are transcriptionally activated during transformation. (B) The network showing genes in the loop are common targets STAT3, NFκb1, JUN, JUNB, and FOS. The nodes represent genes in the loop. The edges represent binding of transcription factors in promoters/enhancers of target genes.
