Fig. 7.

Correlation between inflammation index, cancer progression index, and tumor purity. (A) Correlation between tumor purity, levels of infiltrating immune cells (CD8⁺/CD4⁺ T cells and macrophages), and cancer inflammation index of breast cancer patient samples. (B) Randomly picked breast tumor samples with different inflammation levels and similar purity were examined for gene expression levels in the indicated oncogenic pathways that are direct targets of STAT3/NF-κb/AP-1 and also show significant positive correlation of expression with the cancer inflammation index in Fig. 6B. Genes associated with immune/inflammatory response were removed from the analyses. (C) Randomly picked tumor samples with different inflammation levels and similar purity were examined for expression levels of target genes of STAT3/NF-κb/AP1 in lung cancers, head and neck cancers, glioblastomas, and melanoma. (D) Correlation between inflammation index and cancer progression index. (E) Correlation between tumor purity and cancer progression index.