Figure 4:

Characteristics of participants with MCI with the VCOG signature in ADNI1 and ADNI2. We show the percentage of participants with MCI who (a) progressed to dementia and were (b) APOE4 carriers, (c) female, (d) positive for Aβ measured by a cut-off of 192 pg/mL in the CSF [38], and (e) positive for τ measured by a cut-off of 93 pg/mL in the CSF [38] in each classification (high confidence, low confidence, and negative). (f) Age and (g) cognitive trajectories, measured by the Alzheimer's Disease Assessment Scale-Cognitive subscale with 13 items (ADAS13), across the 3 classes. Significant differences are denoted by asterisks for family-wise error rate-corrected P < 0.05.