Figure 3. Effects of low-density lipoprotein cholesterol (LDL-C) on vascular disease in prospective studies, randomized statin trials, and genetic studies.
Genetic effect of LDL-C on disease was estimated based on 62 variants associated with LDL-C (see primary analysis methods). Estimates from prospective studies are shown for usual levels of non-high-density lipoprotein cholesterol.10 Estimates from randomized statin trial for coronary heart disease are based on major coronary events (coronary death or nonfatal myocardial infarction).7 Estimates from genetic studies are taken from figure 2. CI = confidence interval.